Cycobalamin ndi imodzi mwazinthu za vitamini B, zomwe zimakhala ndi anti-pernicious anemia effect. Ndilo dzina loperekedwa ndi crystallization ya vitamini B12, chinthu chofunikira kwambiri pakukula kwa mabakiteriya ndi nyama. Kupatula C, H, O, N, P ndi Co, aD-ribose conjugate ya 5,6-dimethe-rbenzimidazole ndi gawo la kapangidwe kake. AR Todd et al. perekani njira yopangira, yomwe imatchedwa cyanocobalamin chifukwa cyano imagwirizanitsidwa ndi cobalt. Mayamwidwe pazipita mu njira amadzimadzi ndi 278,361,548 nm. Mu 1948, E．L.Rickes waku United States ndi E. Kuyambira pamenepo, chinthu ichi chapezekanso kuchokera ku actinomycete inayake (StrePtomyces griseum). Cyanocobalamin ndiyenso kukula kwa nkhumba ndi anapiye, ndipo ndi chinthu chofanana ndi mapuloteni anyama omwe amafunikira pakuswa dzira. Vitamini B12, woperekedwa kwa odwala zilonda matenda pa 150 micrograms, akhoza kuonjezera maselo ofiira pafupifupi 2 zina, ndi 3-6 micrograms nawonso kutulutsa zotsatira. Mu vivo, imasamutsidwa m'magazi ngati osakanikirana ndi mapuloteni a trans-cobalamin (mapuloteni a globular), ndipo amapezeka mu mawonekedwe a coenzyme m'magulu osiyanasiyana. Pamodzi ndi kupatsidwa folic acid, imakhudzidwa ndi kagayidwe ka methyl kusamutsa komanso kutulutsa kwa methyl. Ndipo kukhala chinthu chofunikira cha purine, pyrimidine ndi biosynthesis ina.
